Understanding the link between gestational diabetes and heart disease: High glucose levels found to prevent heart cells from maturing normally

High glucose levels, regardless if they are caused by diabetes or other factors, were found to prevent heart cells from maturing normally, according to scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at the University of California, Los Angeles (UCLA).

The results of the study reveal the reason why babies born to women with diabetes have a higher chance of developing congenital heart disease.

Atsushi “Austin” Nakano, a UCLA associate professor of molecular, cell, and developmental biology and member of the Broad Stem Cell Research Center, led the study.

Per the team of researchers, “when developing heart cells are exposed to high levels of glucose,” cells generate more building blocks of DNA than usual. This causes the cells to keep reproducing instead of maturing.

Nakano said, “High blood sugar levels are not only unhealthy for adults; they’re unhealthy for developing fetuses… Understanding the mechanism by which high blood sugar levels cause disease in the fetus may eventually lead to new therapies.”

While genetics is a significant factor in the development of congenital heart disease, one leading non-genetic risk factor for the disease is a pregnant woman diagnosed with diabetes during pregnancy. Babies born to women with high levels of glucose in their blood during pregnancy are twice or even five times more likely be diagnosed with diabetes than other infants. The problem is, scientists are unable to isolate the specific effect of glucose on the developing fetus. (Related: Nutritional supplement helps prevent gestational diabetes.)

Nakano et al. worked with human embryonic stem cells to grow cardiomyocyte (heart muscle cells) in the lab which was then exposed to different glucose levels. Cells exposed to small amounts of glucose matured normally, but cardiomyocytes combined with high levels of glucose matured late or failed to mature altogether. The second batch of cardiomyocyte even “generated more immature cells.”

Because of the extra glucose, “the cardiomyocytes over-activated the pentose phosphate pathway,” which is a cellular process that generates nucleotides, or the building blocks of DNA. In cells with high glucose levels, the pentose phosphate pathway made more nucleotides than usual. The scientists showed that the excess of building blocks kept the cells from maturing.

Nakano shares that when it comes to these cells, more nutrition can actually be bad for them. Depleting glucose at a specific development point can help the cells mature and strengthen the heart muscle.

Nakano adds that the results of their study can pave the way for improved methods of forming cardiomyocytes from stem cells. Though most protocols for generating cardiomyocytes in the lab lead to immature cells, focusing on the pentose phosphate pathway “could help generate more mature cells for regenerating heart cells or for research purposes.”

Foods that can decrease blood sugar for pregnant women

If you’re with child and are diagnosed with diabetes, try to eat more of the foods below to lower your blood sugar:

• Low glycemic index foods — Also known as foods that help reduce inflammation and lower blood sugar levels, low glycemic index foods include beans, sunflower and pumpkin seeds, whole intact grains (e.g. oats, wheat, and barley, and most vegetables and fruits.
• Probiotic-rich foods and supplements — You can optimize your gut bacteria by eating probiotic-rich foods and supplements. Beneficial microbes in the gut can help you balance your blood sugar by regulating carbohydrate metabolism. Eat foods such as kimchi, kombucha, multi-probiotic supplement, natural yogurt with active cultures or kefir also supply healthy bacteria.
• Foods rich in healthy fats — Healthy, “clean-burning” fats such as coconut and olive oils, grass-fed butter (butter made from the milk or cream of grass-fed cows), and walnuts are good for you. Fatty acids keep you feeling full longer, helping to resist unhealthy binges.

Sources include:

ScienceDaily.com

Mom.me