Medicine News

Using chaga mushrooms as proproliferative agents on human follicle dermal papilla cells


Researchers at Tokushima University in Japan screened chaga mushrooms (Inonotus obliquus) for potential anti-alopecia agents. They reported their findings in an article published in the Journal of Natural Medicines.

  • I. obliquus is a parasitic fungus that grows in birch and other trees.
  • Chaga mushrooms, which are used in traditional medicine, refer to the resting body (sclerotium) of I. obliquus.
  • This medicinal fungus is traditionally used in Mongolia to make shampoo that helps maintain healthy hair.
  • The researchers obtained five lanostane-type triterpenes (1-5) via bioassay-guided fractionation of chaga mushroom extracts.
  • They identified the structures of the triterpenes using spectroscopy.
  • Proliferation assay using human follicle dermal papilla cells (HFDPCs) revealed that four of the five triterpenes have pro-proliferative effects on HFDPCs.
  • These compounds were lanosterol (1), inotodiol (3), lanost-8,24-diene-3B,21-diol (4) and trametenolic acid (5).
  • The researchers also reported that these lanostane-type triterpenes (1, 3, 4 and 5) were more potent than minoxidil, a conventional treatment for hair loss.

Based on these findings, the researchers concluded that the lanostane-type triterpenes in chaga mushrooms are potent anti-alopecia agents that can be used to stimulate hair growth naturally.

Journal Reference:

Sagayama K, Tanaka N, Fukumoto T, Kashiwada Y. LANOSTANE-TYPE TRITERPENES FROM THE SCLEROTIUM OF INONOTUS OBLIQUUS (CHAGA MUSHROOMS) AS PROPROLIFERATIVE AGENTS ON HUMAN FOLLICLE DERMAL PAPILLA CELLS. Journal of Natural Medicines. 31 January 2019;73(3):597–601. DOI: 10.1007/s11418-019-01280-0

Get Our Free Email Newsletter
Get independent news alerts on natural cures, food lab tests, cannabis medicine, science, robotics, drones, privacy and more.
Your privacy is protected. Subscription confirmation required.


Comments
comments powered by Disqus

Get Our Free Email Newsletter
Get independent news alerts on natural cures, food lab tests, cannabis medicine, science, robotics, drones, privacy and more.
Your privacy is protected. Subscription confirmation required.

RECENT NEWS & ARTICLES

Get the world's best independent media newsletter delivered straight to your inbox.
x

By continuing to browse our site you agree to our use of cookies and our Privacy Policy.