Dihydrosterculic acid can boost liver metabolism

In this study, published in the journal Nutrition Research, American researchers tested their hypothesis that increasing polyunsaturated fatty acid (PUFA) intake will increase peroxisome proliferator-activated receptor delta (PPARdelta) expression and activity, and examined the effect of PUFA-enriched oils on muscle PPARdelta expression. One of the oils they tested was cottonseed oil (CSO) which contains dihydrosterculic acid (DHSA), a fatty acid that helps prevent the accumulation of triglycerides in the body.

• Male mice were used for the experiment; they were fed either chow, CSO-enriched diets, saturated fat (SFA)-enriched diets, or linoleic acid-enriched diets for four weeks.
• Researchers found that mice fed a CSO-enriched diet displayed no change in PPARdelta expression in the muscles.
• Mice that were fed chow and a CSO-enriched diet did not differ in terms of food intake, body weight, fasting glucose, glucose tolerance, and energy expenditure. SFA-fed mice had increased fat mass while mice fed a linoleic acid-enriched diet had low glucose tolerance.
• PPARdelta expression was elevated in the liver of CSO-fed mice together with its transcriptional coactivator Pgc-1.
• Metabolic analyses revealed that the livers of CSO-fed mice and chow-fed mice were similar but significantly differed from the livers of SFA-fed mice and linoleic acid-fed mice.
• CSO-fed mice exhibited low desaturase activity due to the presence of DHSA. DHSA alone had the same effect on PPARdelta expression and stearoyl-CoA desaturase-1 expression. Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism.

Based on their findings, the researchers concluded that DHSA from CSO can be used to increase PPARdelta expression and simultaneously lower liver stearoyl-CoA desaturase-1 activity.

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Journal Reference:

Paton CM, Vaughan RA, Alpergin ESS, Assadi-Porter F, Dowd MK. DIHYDROSTERCULIC ACID FROM COTTONSEED OIL SUPPRESSES DESATURASE ACTIVITY AND IMPROVES LIVER METABOLOMIC PROFILES OF HIGH-FAT–FED MICE. Nutrition Research. September 2017;45:52–62. DOI: 10.1016/j.nutres.2017.06.008