05/31/2019 / By Evangelyn Rodriguez
In this study published in the journal Nutrition Research, a team of researchers from the David Geffen School of Medicine at the University of California, Los Angeles investigated the mechanisms underlying intrauterine growth restriction (IUGR) using a mouse model. They evaluated key cytokines like interleukin-10 (IL-10), cellular processes related to immunity, and the resulting IUGR phenotype and placental histopathology to determine the immunologic pathways affected by IUGR.
The researchers concluded that FR causes IUGR by triggering changes in gene expression in a placental level that involves immunologic pathways and associated cellular maintenance processes.
Journal Reference:
Chu A, Thamotharan S, Ganguly A, Wadehra M, Pellegrini M, Devaskar SU. GESTATIONAL FOOD RESTRICTION DECREASES PLACENTAL INTERLEUKIN-10 EXPRESSION AND MARKERS OF AUTOPHAGY AND ENDOPLASMIC RETICULUM STRESS IN MURINE INTRAUTERINE GROWTH RESTRICTION. Nutrition Research. October 2016;36(10):1055–1067. DOI: 10.1016/j.nutres.2016.08.001
Tagged Under: autophagy, Birth defects, cellular maintenance, cytokines, fetal growth restriction, fetus, gestation, immunotolerance, inflammation, intrauterine growth restriction, maternal diet, maternal food restriction, maternal nutrition, pregnancy, research, trophoblast, women's health