06/11/2019 / By Evangelyn Rodriguez
In this study, researchers from Kagoshima University in Japan and Vietnam National University of Agriculture evaluated the antagonistic effects of Ginkgo biloba (GB) and Sophora japonica (SJ) on cerebral vasoconstriction in response to KCl, extracellular Ca2+, histamine, 5-hydroxytryptamine (5-HT), 9,11-dideoxy-9alpha,11alpha-methanoepoxy prostaglandin (PG) F2alpha(U46619), and bradykinin (BK). The results of their study, which explain the traditional application of these plants in the treatment of diseases associated with cerebral vasospasm, were published in The American Journal of Chinese Medicine.
The researchers concluded that SJ and GB have a H1-antagonistic effect, with SJ also having the ability to attenuate cerebral vasoconstriction mediated via 5-HT2 and TXA2/PG receptors, which may be why SJ has been used traditionally as a therapeutic medication for cerebral vasospasm after cerebral hemorrhage.
Journal Reference:
Nguyen HTT, Nguyen HT, Islam MZ, Obi T, Pothinuch P, Nguyen TV, Nguyen TM, Dao CV, Shiraishi M, Miyamoto A. ANTAGONISTIC EFFECTS OF GINGKO BILOBA AND SOPHORA JAPONICA ON CEREBRAL VASOCONSTRICTION IN RESPONSE TO HISTAMINE, 5-HYDROXYTRYPTAMINE, U46619 AND BRADYKININ. The American Journal of Chinese Medicine. 2016;44(08):1607–1625. DOI: 10.1142/s0192415x16500907
Tagged Under: alternative medicine, blood vessels, brain health, cardiovascular health, cerebral hemorrhage, cerebral vasoconstriction, cerebral vasospasm, cognitive health, disease treatments, ginkgo biloba, herbal medicine, Herbs, natural cures, natural medicine, prevention, remedies, research, Sophora japonica, TCM, traditional Chinese medicine